3H-Pyrazol-3-one,5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
- 中文别名：氯唑啉胺
- 中文释义：氯唑啉胺;莫唑胺
- 英文别名：5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one;
Muzolimina [Spanish];
EINECS 259-573-2;
Muzolimina [INN-Spanish];
Muzoliminum [INN-Latin];
5-amino-2-[1-(3,4-dichloro-phenyl)-ethyl]-1,2-dihydro-pyrazol-3-one;
Edrul;
BAY G 2821;
MUZOLIMINE
- CAS No.：55294-15-0
- 分子式：C11H11Cl2N3O
- 分子量：272.134
- 精确分子量：271.02800
- PSA：56.19000
- InChI：The Key: RLWRMIYXDPXIEX-UHFFFAOYSA-N
- 分子结构式：
物化性质
- 密度：
- 1.51g/cm3
- 沸点：
- 401.4ºC at 760 mmHg
- 闪点：
- 196.6ºC
- 折射率：
- 1.666
安全信息
- 密度：
- 1.51g/cm3
- 沸点：
- 401.4ºC at 760 mmHg
- 闪点：
- 196.6ºC
- 折射率：
- 1.666
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UR0370000
- CHEMICAL NAME :
- 3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-
- CAS REGISTRY NUMBER :
- 55294-15-0
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C11-H11-Cl2-N3-O
- MOLECULAR WEIGHT :
- 272.15
- WISWESSER LINE NOTATION :
- T5NNV DHJ BY1&R CG DG& EZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1559 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory obstruction Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 221 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- CLNHBI Clinical Nephrology. (Dustri-Verlag Dr. Karl Feistle, Postfach 49, D-8024 Munich-Deisenhofen, Fed. Rep. Ger.) V.1- 1973- Volume(issue)/page/year: 19(Suppl 1),20,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1794 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory obstruction Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 310 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis
- REFERENCE :
- CLNHBI Clinical Nephrology. (Dustri-Verlag Dr. Karl Feistle, Postfach 49, D-8024 Munich-Deisenhofen, Fed. Rep. Ger.) V.1- 1973- Volume(issue)/page/year: 19(Suppl 1),20,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLNHBI Clinical Nephrology. (Dustri-Verlag Dr. Karl Feistle, Postfach 49, D-8024 Munich-Deisenhofen, Fed. Rep. Ger.) V.1- 1973- Volume(issue)/page/year: 19(Suppl 1),20,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1250 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory obstruction Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9 gm/kg/13W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
- REFERENCE :
- CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1620 mg/kg/13W-I
- TOXIC EFFECTS :
- Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume increased Related to Chronic Data - death
- REFERENCE :
- CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 84 mg/kg/4W-I
- TOXIC EFFECTS :
- Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - dehydration
- REFERENCE :
- CMROCX Current Medical Research and Opinion. (Clayton-Wray Pub. Ltd., 1a High St., Alton, Hants., UK) V.1- 1972- Volume(issue)/page/year: 4,716,1977
