1H-Pyrano[3,4-c]pyridin-1-one,5-ethenyl-3,4-dihydro-
- 中文别名：秦艽甲素
- 中文释义：秦艽甲素
- 英文别名：gentianine;
5-vinyl-pyrrolidin-2-one;
4-<2-Hydroxyaethyl>-5-vinyl-3-pyridin-carboxylic acid lacton;
2-Pyrrolidinone,5-ethenyl;
Gentianine;
5-VINYLPYRROLIDONE;
5-vinylpyrrolidinone
- CAS No.：439-89-4
- 分子式：
C10H9NO2
- 分子量：175.18
- 精确分子量：175.06300
- PSA：39.19000
- InChI：InChI=1/C10H9NO2/c1-2-7-5-11-6-9-8(7)3-4-13-10(9)12/h2,5-6H,1,3-4H2
- 分子结构式：
物化性质
- 密度：
- 1.225g/cm3
- 熔点：
- 84-86ºC
- 沸点：
- 386.5ºC at 760mmHg
- 闪点：
- 187.6ºC
- 折射率：
- 1.604
- 蒸汽压：
- 3.52E-06mmHg at 25°C
安全信息
- 密度：
- 1.225g/cm3
- 熔点：
- 84-86ºC
- 沸点：
- 386.5ºC at 760mmHg
- 闪点：
- 187.6ºC
- 折射率：
- 1.604
- 蒸汽压：
- 3.52E-06mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ1374500
- CHEMICAL NAME :
- 1H-Pyrano(3,4-c)pyridin-1-one, 3,4-dihydro-5-vinyl-
- CAS REGISTRY NUMBER :
- 439-89-4
- BEILSTEIN REFERENCE NO. :
- 0137011
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H9-N-O2
- MOLECULAR WEIGHT :
- 175.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 276 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,1341,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 7,1,1983
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 25,258,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 26,333,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PAHEAA Pharmaceutica Acta Helvetiae. (Schweizerische Apothekerzeitung, Postfach 3006, CH3000 Bern, 7, Switzerland) V.1- 1926- Volume(issue)/page/year: 26,333,1951
