1,2,3,4-Butanetetrol,1,4-dimethanesulfonate, (2S,3S)-
- 中文别名：曲奥舒凡
- 中文释义：曲奥舒凡
- 英文别名：(2S,3S)-Threitol 1,4-bismethanesulfonate;
Dihydroxybusulfan;
L-threitol 1,4-bismethane sulfonate;
treosulfan;
THREOSULFAN;
TREOSULPHAN;
L-Dihydroxy-Busulfan;
CB-2562;
Dihydroxymyleran
- CAS No.：299-75-2
- 分子式：
C6H14O8S2
- 分子量：278.30
- 精确分子量：278.01300
- PSA：143.96000
- InChI：The Key: YCPOZVAOBBQLRI-WDSKDSINSA-N
- 分子结构式：
物化性质
- 密度：
- 1.562g/cm3
- 沸点：
- 607ºC at 760mmHg
- 闪点：
- 320.9ºC
- 折射率：
- 1.518
- 蒸汽压：
- 0mmHg at 25°C
安全信息
- 密度：
- 1.562g/cm3
- 沸点：
- 607ºC at 760mmHg
- 闪点：
- 320.9ºC
- 折射率：
- 1.518
- 蒸汽压：
- 0mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XO8500000
- CHEMICAL NAME :
- L-Threitol, 1,4-bismethanesulfonate
- CAS REGISTRY NUMBER :
- 299-75-2
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C6-H14-O8-S2
- MOLECULAR WEIGHT :
- 278.32
- WISWESSER LINE NOTATION :
- WS1&O1YQYQ1OSW1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 222 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Blood - leukopenia Blood - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 222 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - agranulocytosis Blood - other changes
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,95,1993 *** REVIEWS *** IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,341,1981 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,341,1981 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,363,1987
