3-Hydroxy-alpha-methyl-DL-tyrosine
- 中文别名：DL-甲基多巴
- 中文释义：DL-甲基多巴;3-羟基-alpha-甲基-DL-酪氨酸;2-甲基-3-(3,4-二羟基苯基)-DL-丙氨酸
- 英文别名：2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;
EINECS 209-088-7;
Metholes;
Mulfasin
- CAS No.：555-29-3
- 分子式：
C10H13NO4
- 分子量：211.22
- 精确分子量：211.08400
- PSA：103.78000
- InChI：InChI=1/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m1/s1
- 分子结构式：
物化性质
- 密度：
- 1.403g/cm3
- 沸点：
- 441.6ºC at 760 mmHg
- 闪点：
- 220.9ºC
- 折射率：
- 1.635
安全信息
- 密度：
- 1.403g/cm3
- 沸点：
- 441.6ºC at 760 mmHg
- 闪点：
- 220.9ºC
- 折射率：
- 1.635
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AY5940000
- CHEMICAL NAME :
- Alanine, 3-(3,4-dihydroxyphenyl)-2-methyl-, DL-
- CAS REGISTRY NUMBER :
- 555-29-3
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C10-H13-N-O4
- MOLECULAR WEIGHT :
- 211.24
- WISWESSER LINE NOTATION :
- QVXZ1&1R CQ DQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5710 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 430 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5370 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1317 mg/kg
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1318,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1760 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-348,1989
