mannomustine

物化性质

密度：

1.353g/cm3

沸点：

541.9ºC at 760 mmHg

闪点：

281.5ºC

折射率：

1.544

安全信息

密度：

1.353g/cm3

沸点：

541.9ºC at 760 mmHg

闪点：

281.5ºC

折射率：

1.544

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

OP2100000

CHEMICAL NAME :

Mannitol, 1,6-bis((2-chloroethyl)amino)-1,6-dideoxy-, D-,

CAS REGISTRY NUMBER :

576-68-1

LAST UPDATED :

199707

DATA ITEMS CITED :

13

MOLECULAR FORMULA :

C10-H22-Cl2-N2-O4

MOLECULAR WEIGHT :

305.24

WISWESSER LINE NOTATION :

G2M1YQYQYQYQ1M2G -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

56 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

56 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

90 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

90 mg/kg

TOXIC EFFECTS :

Tumorigenic - protects against induction of experimental tumors

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

50 mg/kg

TOXIC EFFECTS :

Blood - leukopenia

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

20 mg/kg

TOXIC EFFECTS :

Blood - changes in spleen Tumorigenic - protects against induction of experimental tumors

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Rodent - hamster Cells - not otherwise specified

DOSE/DURATION :

2900 nmol/L

REFERENCE :

SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966- Volume(issue)/page/year: 18,210,1982