oleandomycin

物化性质

密度：

1.21g/cm3

沸点：

802.6ºC at 760 mmHg

闪点：

439.2ºC

折射率：

1.533

安全信息

密度：

1.21g/cm3

沸点：

802.6ºC at 760 mmHg

闪点：

439.2ºC

折射率：

1.533

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

RJ9220000

CHEMICAL NAME :

Oleandomycin

CAS REGISTRY NUMBER :

3922-90-5

LAST UPDATED :

199012

DATA ITEMS CITED :

8

MOLECULAR FORMULA :

C35-H61-N-O12

MOLECULAR WEIGHT :

687.97

WISWESSER LINE NOTATION :

T-14-VO GVXTJ C1 D1 EQ F1 J1 L1 N1 H-& BT3OX CHJ& KO- BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6700 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946- Volume(issue)/page/year: 39,259,1978

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10 gm/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :

HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

440 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :

HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

8200 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :

HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2500 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :

HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

460 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,475,1967

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :

HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

2343 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - ataxia

REFERENCE :

HMACAX Helvetica Medica Acta. (Basel, Switzerland) V.1-37, 1934-1974. For publisher information, see SMWOAS. Volume(issue)/page/year: 23,714,1956