1,2-二甲肼,CAS号:540-73-8,msds,分子式-找单词

英语词典化工词典

1，2-Dimethyl hydrazine

中文别名：1,2-二甲肼
中文释义：1,2-二甲基肼;二甲基肼(对称);对称二甲基肼;1,2-二甲肼
英文别名：1,2-dimethylhydrazine;
Hydrazine,1,2-dimethyl;
1,2-dimethyl hydrazine;
Hydrazomethane;
1,2-Dimethylhydrazin;
sym-Dimethylhydrazine;
Symmetrical-dimethylhydrazine;
SDMH;
N,N'-dimethyl-hydrazine
CAS No.：540-73-8
分子式：
C2H8N2
分子量：60.0992
精确分子量：60.06870
PSA：24.06000
InChI：The Key: DIIIISSCIXVANO-UHFFFAOYSA-N
分子结构式：

物化性质

外观与性状：

无色带氮气味的液体，有吸湿性的液体

密度：

0.759g/cm3

沸点：

81.5ºC at 760mmHg

存储条件/存储方法：

库房通风低温干燥,与酸,氧化剂分开储运存放

稳定性相关：

1.稳定性^[16] 稳定

2.禁配物^[17] 氧化剂、铜及其合金、铁、铁盐

3.避免接触的条件^[18] 受热

4.聚合危害^[19] 不聚合

其它信息：

1.性状：无色带氨气味的液体，有吸湿性的液体。^[1]

2.熔点（℃）：-9^[2]

3.沸点（℃）：81^[3]

4.相对密度（水=1）：0.83（20℃）^[4]

5.饱和蒸气压（kPa）：9.32（25℃）^[5]

6.辛醇/水分配系数：-0.54（计算）^[6]

7.闪点（℃）：23（CC）^[7]

8.溶解性：与水混溶，溶于乙醇、乙醚。^[8]

安全信息

外观与性状：

无色带氮气味的液体，有吸湿性的液体

密度：

0.759g/cm3

沸点：

81.5ºC at 760mmHg

存储条件/存储方法：

库房通风低温干燥,与酸,氧化剂分开储运存放

稳定性相关：

1.稳定性^[16] 稳定

2.禁配物^[17] 氧化剂、铜及其合金、铁、铁盐

3.避免接触的条件^[18] 受热

4.聚合危害^[19] 不聚合

其它信息：

1.性状：无色带氨气味的液体，有吸湿性的液体。^[1]

2.熔点（℃）：-9^[2]

3.沸点（℃）：81^[3]

4.相对密度（水=1）：0.83（20℃）^[4]

5.饱和蒸气压（kPa）：9.32（25℃）^[5]

6.辛醇/水分配系数：-0.54（计算）^[6]

7.闪点（℃）：23（CC）^[7]

8.溶解性：与水混溶，溶于乙醇、乙醚。^[8]

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MV2625000

CHEMICAL NAME :: Hydrazine, 1,2-dimethyl-

CAS REGISTRY NUMBER :: 540-73-8

BEILSTEIN REFERENCE NO. :: 1730826

LAST UPDATED :: 199707

DATA ITEMS CITED :: 88

MOLECULAR FORMULA :: C2-H8-N2

MOLECULAR WEIGHT :: 60.12

WISWESSER LINE NOTATION :: 1MM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 163 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 176 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Sense Organs and Special Senses (Eye) - effect, not otherwise specified

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 260 mg/kg/13W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 90 mg/kg/28W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Eye) - effect, not otherwise specified Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg/16W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12500 ug/kg/24W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg/24W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg/18W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 400 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 608 mg/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 340 mg/kg/17W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg/12W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg/4W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg/11W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 42 mg/kg/28W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Gastrointestinal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 420 mg/kg/28W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg/10W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,93,1983 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,145,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,145,1974 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 39,111,1977 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.2 mg/m3);STEL 0.2 ppm (0.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.5 ppm (1.2 mg/m3);Skin;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120MREFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

毒理学数据：

1.急性毒性^[9]

LD50：100mg/kg（大鼠经口）；36mg/kg（小鼠经口）

LC50：700~1000mg/m³（大鼠吸入，4h）

2.刺激性 暂无资料

3.致突变性^[10] 微生物致突变：鼠伤寒沙门菌25μg/皿。DNA加合物：人肺1290μmol/L。程序外DNA合成：人肺100μl/L。

4.致癌性^[11] IARC致癌性评论：G2A，人类可能致癌物。

5.其他^[12] LCLo：280ppm（大鼠吸入，4h）

生态数据：

1.生态毒性 暂无资料

2.生物降解性^[13]

好氧生物降解（h）：168~672

厌氧生物降解（h）：672~2688

3.非生物降解性^[14] 空气中光氧化半衰期（h）：0.5~5.2

4.其他有害作用^[15] 该物质对环境有危害，对鱼类应给予特别注意。在环境中能被生物降解。

MSDS

国标编号:	32184
ＣＡＳ:	540-73-8
中文名称:	1,2-二甲基肼
英文名称:	Dimethyl hydrazine(symmetrical)；1,2-Dimethyl hydrazine
别名:	二甲基肼(对称)
分子式:	C₂H₈N₂；H₃CNHNHCH₃
分子量:	60.12
熔点:	-9℃ 沸点：81℃
密度:	相对密度(水=1)0.83(2
蒸汽压:	<23℃
溶解性:	与水混溶，溶于乙醇、醚
稳定性:	稳定
外观与性状:	无色带氮气味的液体，有吸湿性的液体
危险标记:	7(易燃液体)
用途:

2.对环境的影响:
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：误服、吸入蒸气或经皮肤吸收会中毒，并能灼伤皮肤。蒸气对粘膜有刺激作用。
二、毒理学资料及环境行为
急性毒性：LD50100mg/kg(大鼠经口)
致癌性：IARC致癌性评论：对人可能致癌。
危险特性：其蒸气与空气形成爆炸性混合物，遇明火、高热极易燃烧爆炸。与氧化剂能发生强烈反应，引起燃烧或爆炸。
燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。
3.现场应急监测方法:
　
4.实验室监测方法:
氨基亚铁氰化钠分光光度法(GB/T14376-93，水质)
气相色谱法；分光光度法《空气和废气监测分析方法》，国家环保局编
5.环境标准:
前苏联车间空气中有害物质的最高容许浓度 0.1mg/m3
6.应急处理处置方法:
一、泄漏应急处理
疏散泄漏污染区人员至安全区，禁止无关人员进入污染区。应急处理人员戴自给式呼吸器，穿厂商特别推荐的化学防护服(完全隔离)。不要直接接触泄漏物。在确保安全情况下堵漏。用大量水冲洗，经稀释的洗液放入废水系统。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。
二、防护措施
呼吸系统防护：可能接触其蒸气时，应该佩戴防毒口罩。紧急事态抢救或撤离时，建议佩戴自给式呼吸器。
眼睛防护：戴化学安全防护眼镜。
身体防护：穿防腐工作服。
手防护：戴防化学品手套。
其它：工作现场严禁吸烟。工作后，淋浴更衣。实行就业前和定期的体检。保持良好的卫生习惯。
三、急救措施
皮肤接触：脱去污染的衣着，用肥皂水及清水彻底冲洗。若有灼伤，就医治疗。
眼睛接触：立即翻开上下眼睑，用流动清水冲洗15分钟。就医。
吸入：迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入：误服者用水漱口，饮牛奶或蛋清，就医。
灭火方法：大火可用水，小火可用二氧化碳、干粉、砂土。

分子结构与计算化学数据

分子结构数据

1、摩尔折射率：18.5

2、摩尔体积（cm³/mol）：79.1

3、等张比容（90.2K）：167.6

4、表面张力（dyne/cm）：20.0

5、介电常数：无可用的

6、极化率：7.33

7、单一同位素质量：60.068748 Da

8、标称质量：60 Da

9、平均质量：60.0983 Da

计算化学数据

1.疏水参数计算参考值（XlogP）:-0.4

2.氢键供体数量:2

3.氢键受体数量:2

4.可旋转化学键数量:1

5.互变异构体数量:无

6.拓扑分子极性表面积24.1

7.重原子数量:4

8.表面电荷:0

9.复杂度:6

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

1，2-Dimethyl hydrazine

1，2-Dimethyl hydrazine

物化性质

安全信息

毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

MSDS

分子结构与计算化学数据

分子结构数据

计算化学数据

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热门化工词典词汇