10H-Phenothiazine-2-sulfonamide,N,N-dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]-
- 中文别名：硫丙拉嗪; 氨砜拉嗪; 磺丙拉嗪; N,N-二甲基-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪-2-磺酰胺
- 中文释义：硫丙拉嗪;N,N-二甲基-10-[3-(4-甲基哌嗪-1-基)丙基]吩噻嗪-2-磺酰胺;氨砜拉嗪;磺丙拉嗪
- 英文别名：thioproperazine;
2-Dimethylsulfamoyl-10-<3-(4-methyl-piperazin-1-yl)-propyl>-phenothiazin;
10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine-2-sulfonic acid dimethylamide;
Majeptyl;
Megeptil;
Thioproperazine;
Sulfenazin;
N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide;
10-<3-(4-Methyl-piperazin-1-yl)-propyl>-phenothiazin-2-sulfonsaeure-dimethylamid;
Cephalmin;
Thioperazine;
Mazeptyl;
Thioproperazin;
thiproperazine;
Vontil;
Tioproferazina
- CAS No.：316-81-4
- 分子式：
C22H30N4O2S2
- 分子量：446.63
- 精确分子量：446.18100
- PSA：80.78000
- InChI：The Key: VZYCZNZBPPHOFY-UHFFFAOYSA-N
- 分子结构式：
物化性质
- 密度：
- 1.237g/cm3
- 熔点：
- 140ºC
- 沸点：
- 612.2ºC at 760mmHg
- 闪点：
- 324ºC
- 折射率：
- 1.615
安全信息
- 密度：
- 1.237g/cm3
- 熔点：
- 140ºC
- 沸点：
- 612.2ºC at 760mmHg
- 闪点：
- 324ºC
- 折射率：
- 1.615
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SP5400000
- CHEMICAL NAME :
- Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-
- CAS REGISTRY NUMBER :
- 316-81-4
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C22-H30-N4-O2-S2
- MOLECULAR WEIGHT :
- 446.68
- WISWESSER LINE NOTATION :
- T C666 BN ISJ ESWN1&1 B3- AT6N DNTJ D1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 830 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 1-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/kg
- REFERENCE :
- CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(5),14,1975
海关数据
中国海关编码：2935009090
- 概述：
- 2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
- 申报要素：
- 品名, 成分含量, 用途
- 摘要/Summary：
- 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%
分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:0
3.氢键受体数量:7
4.可旋转化学键数量:6
5.互变异构体数量:无
6.拓扑分子极性表面积:80.8
7.重原子数量:30
8.表面电荷:0
9.复杂度:661
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
