10H-Phenothiazine-10-propanamine,2-methoxy-N,N-dimethyl-
- 中文别名：美索丙嗪
- 中文释义：美索丙嗪
- 英文别名：3-(2-methoxyphenothiazin-10-yl)-N,N-dimethylpropan-1-amine;
2-Methoxypromazine;
Methopromazinum [INN-Latin];
Neoproma;
[3-(2-methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amine;
RP 4632;
Methoxypromazine;
Tentone;
2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine;
Methopromazine;
Tenton;
Methopromazin;
Metopromazina [INN-Spanish];
Levopromazine;
[3-(2-Methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amin
- CAS No.：61-01-8
- 分子式：
C18H22N2OS
- 分子量：314.48
- 精确分子量：314.14500
- PSA：41.01000
- InChI：The Key: BRABPYPSZVCCLR-UHFFFAOYSA-N
- 分子结构式：
物化性质
- 密度：
- 1.143g/cm3
- 沸点：
- 461.8ºC at 760 mmHg
- 闪点：
- 233.1ºC
- 折射率：
- 1.603
安全信息
- 密度：
- 1.143g/cm3
- 沸点：
- 461.8ºC at 760 mmHg
- 闪点：
- 233.1ºC
- 折射率：
- 1.603
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SO7600000
- CHEMICAL NAME :
- Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
- CAS REGISTRY NUMBER :
- 61-01-8
- LAST UPDATED :
- 198209
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H22-N2-O-S
- MOLECULAR WEIGHT :
- 314.48
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B3N1&1 EO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 730 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 95 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 408 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 112 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960
