1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-
- 中文别名：盐酸石蒜碱
- 中文释义：盐酸石蒜碱;石蕊碱;石蒜碱
- 英文别名：Lycorine hydrochloride;
Lycorinehydrochloride;
Lycorinechloride;
Licorin hydrochloride;
galanthidine,hydrochloride
- CAS No.：2188-68-3
- 分子式：
C16H17NO4.ClH
- 分子量：323.77
- 精确分子量：287.11600
- PSA：62.16000
- InChI：InChI=1/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1
- 分子结构式：
物化性质
- 外观与性状：
- 细晶体粉末
- 熔点：
- 210-212ºC
- 沸点：
- 477.4ºC at 760 mmHg
- 闪点：
- 242.5ºC
- 蒸汽压：
- 6.37E-10mmHg at 25°C
安全信息
- 外观与性状：
- 细晶体粉末
- 熔点：
- 210-212ºC
- 沸点：
- 477.4ºC at 760 mmHg
- 闪点：
- 242.5ºC
- 蒸汽压：
- 6.37E-10mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OL2910000
- CHEMICAL NAME :
- Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-, hydrochloride
- CAS REGISTRY NUMBER :
- 2188-68-3
- LAST UPDATED :
- 198803
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C16-H17-N-O4.Cl-H
- MOLECULAR WEIGHT :
- 323.80
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 117 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 123 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958
