4-Piperidinecarboxamide,4-(dimethylamino)-N-(2,6-dimethylphenyl)-1-[(1R,2R)-2-hydroxycyclohexyl]-, rel-
- 中文别名：群司卡尼
- 中文释义：群司卡尼
- 英文别名：Transcainide;
R-54718;
rel-(1R*)-2β*-[4-[(2,6-Dimethylphenyl)carbamoyl]-4-(dimethylamino)piperidino]1β*-cyclohexanol
- CAS No.：88296-62-2
- 分子式：C22H35N3O2
- 分子量：0
- 精确分子量：373.27300
- PSA：55.81000
- 分子结构式：
物化性质
- 密度：
- 1.13g/cm3
- 沸点：
- 529.4ºC at 760 mmHg
- 闪点：
- 274ºC
- 折射率：
- 1.58
安全信息
- 密度：
- 1.13g/cm3
- 沸点：
- 529.4ºC at 760 mmHg
- 闪点：
- 274ºC
- 折射率：
- 1.58
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TM6060000
- CHEMICAL NAME :
- 4-Piperidinecarboxamide, 4-(dimethylamino)-N-(2,6-dimethylphenyl)-1-(2-hydroxy cyclohexyl)-, trans-(+-)-
- CAS REGISTRY NUMBER :
- 88296-62-2
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C22-H35-N3-O2
- MOLECULAR WEIGHT :
- 373.60
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4830 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1500 ug/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 440 ug/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987
