4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-, hydrochloride (1:2)
- 中文别名：4-甲基-N-(2-吗啉-4-乙基)-6-苯基吡嗪-3-胺
- 中文释义：4-甲基-N-(2-吗啉-4-乙基)-6-苯基吡嗪-3-胺
- 英文别名：minaprine hydrochloride;
Ag 620;
Agr 620;
Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride;
Agr 1240;
4-Morpholineethanamine,N-(4-methyl-6-phenyl-3-pyridazinyl)-,dihydrochloride;
Morpholine,4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-,dihydrochloride
- CAS No.：25953-17-7
- 分子式：C17H22N4O.2ClH
- 分子量：0
- 精确分子量：334.15600
- PSA：50.28000
- 分子结构式：
物化性质
- 沸点：
- 531.2ºC at 760 mmHg
- 闪点：
- 275.1ºC
- 蒸汽压：
- 2.29E-11mmHg at 25°C
安全信息
- 沸点：
- 531.2ºC at 760 mmHg
- 闪点：
- 275.1ºC
- 蒸汽压：
- 2.29E-11mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QE3477835
- CHEMICAL NAME :
- 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride
- CAS REGISTRY NUMBER :
- 25953-17-7
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H22-N4-O.2Cl-H
- MOLECULAR WEIGHT :
- 371.35
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 63 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4508720 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4823 mg/kg/13W-I
- TOXIC EFFECTS :
- Endocrine - changes in adrenal weight Endocrine - changes in thymus weight
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 24,1894,1990
