1,2-Ethanediamine,N1-[(4-methoxyphenyl)methyl]-N2,N2-dimethyl-N1-2-pyrimidinyl-, hydrochloride(1:1)
- 中文别名：盐酸嘧啶二胺
- 中文释义：盐酸嘧啶二胺;8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate;Primaquine Phosphate;N~4~-(6-methoxyquinolin-8-yl)pentane-1,4-diamine phosphate (1:2);Primaquine diphosphate;bug master;carbamec;carbamine;carbatox;carbomate;carpolin;carylderm;ceku
- 英文别名：N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyrimidin-2-ylethane-1,2-diamine,hydrochloride;
EINECS 200-561-3;
Thonzylamine HCl;
Neohetramine hydrochloride;
Anahist;
Thonzylaminium chloride;
UNII-6K9YKD48Y4;
Novohetramin;
Resistab;
THONZYLAMINE HYDROCHLORIDE
- CAS No.：63-56-9
- 分子式：
C16H22N4O.ClH
- 分子量：322.88
- 精确分子量：322.15600
- PSA：41.49000
- InChI：InChI=1/C16H22N4O.ClH/c1-19(2)11-12-20(16-17-9-4-10-18-16)13-14-5-7-15(21-3)8-6-14;/h4-10H,11-13H2,1-3H3;1H
- 分子结构式：
物化性质
- 外观与性状：
- 白色结晶粉末
- 熔点：
- 173 - 176ºC
- 沸点：
- 440.6°C at 760 mmHg
- 闪点：
- 220.3ºC
安全信息
- 外观与性状：
- 白色结晶粉末
- 熔点：
- 173 - 176ºC
- 沸点：
- 440.6°C at 760 mmHg
- 闪点：
- 220.3ºC
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV8750000
- CHEMICAL NAME :
- Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, hydrochloride
- CAS REGISTRY NUMBER :
- 63-56-9
- LAST UPDATED :
- 198812
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C16-H22-N4-O.Cl-H
- MOLECULAR WEIGHT :
- 322.88
- WISWESSER LINE NOTATION :
- T6N CNJ BN1R DO1&2N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,419,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 157 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,83S,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 493 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 38200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974
