1H-Indol-4-ol,3-[2-(dimethylamino)ethyl]-, 4-(dihydrogen phosphate)

物化性质

密度：

1.409g/cm3

熔点：

220-228ºC

沸点：

523.4ºC at 760mmHg

闪点：

270.4ºC

折射率：

1.644

存储条件/存储方法：

库房低温,通风,干燥

安全信息

密度：

1.409g/cm3

熔点：

220-228ºC

沸点：

523.4ºC at 760mmHg

闪点：

270.4ºC

折射率：

1.644

存储条件/存储方法：

库房低温,通风,干燥

毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NM3150000

CHEMICAL NAME :

Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate

CAS REGISTRY NUMBER :

520-52-5

BEILSTEIN REFERENCE NO. :

0273158

LAST UPDATED :

199612

DATA ITEMS CITED :

12

MOLECULAR FORMULA :

C12-H17-N2-O4-P

MOLECULAR WEIGHT :

284.28

WISWESSER LINE NOTATION :

T56 BMJ D2N1&1 FOPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

SPECIES OBSERVED :

Human

DOSE/DURATION :

75 ug/kg

TOXIC EFFECTS :

Behavioral - euphoria Behavioral - hallucinations, distorted perceptions

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

60 ug/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - visual field changes Behavioral - muscle weakness Gastrointestinal - nausea or vomiting

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Human

DOSE/DURATION :

37 ug/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - visual field changes Behavioral - muscle weakness Gastrointestinal - nausea or vomiting

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

SPECIES OBSERVED :

Human

DOSE/DURATION :

130 ug/kg

TOXIC EFFECTS :

Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

280 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

420 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

275 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

13 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :

Human

DOSE/DURATION :

229 ug/kg

REFERENCE :

HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ. Volume(issue)/page/year: 9,281,1970 *** REVIEWS *** TOXICOLOGY REVIEW JMTHBU Journal of the Medical Association of Thailand. (Businesss Mgr., Dept. of Microbiology, Faculty of Medicine, Siriraj Hospital, Bangkok 7, Thailand) V.1- 1918- Volume(issue)/page/year: 58,623,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7177 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1358 (estimated) No. of Female Employees: 956 (estimated)