3-Heptanone,6-(dimethylamino)-4,4-diphenyl-, hydrochloride (1:1), (6R)-
- 中文别名：(R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵
- 中文释义：(R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵
- 英文别名：(6R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride (1: 1);
(-)-Mephobarbital;
(R)-(6-dimethylamino-4,4-diphenylheptan-3-one) hydrochloride;
UNII-5NC67NU76B component ALARQZQTBTVLJV-CYBMUJFWSA-N;
(R)-6-dimethylamino-4,4-diphenyl-3-heptanone hydrochloride;
(-)-Methylphenobarbital;
(-)-Methadone hydrochloride;
(6R)-methadone hydrochloride;
(R)-Methylphenobarbital;
(5S)-mephobarbital;
2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-,(R);
(R)-(-)-mephobarbital;
R-(-)-methadone hydrochloride
- CAS No.：5967-73-7
- 分子式：C21H27NO.ClH
- 分子量：345.95
- 精确分子量：345.18600
- PSA：20.31000
- InChI：The Key: FJQXCDYVZAHXNS-UNTBIKODSA-N
- 分子结构式：
物化性质
- 熔点：
- 220-227ºC
- 沸点：
- 423.7ºC at 760 mmHg
- 闪点：
- 126.5ºC
安全信息
- 熔点：
- 220-227ºC
- 沸点：
- 423.7ºC at 760 mmHg
- 闪点：
- 126.5ºC
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MJ6475000
- CHEMICAL NAME :
- 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (-)-
- CAS REGISTRY NUMBER :
- 5967-73-7
- LAST UPDATED :
- 199601
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C21-H27-N-O.Cl-H
- MOLECULAR WEIGHT :
- 345.95
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 44 ug/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - analgesia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,282,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 98,305,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Endocrine - other changes
- REFERENCE :
- BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 10,260,1955
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 97300 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 17,321,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 98,305,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 98,305,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Behavioral - analgesia
- REFERENCE :
- APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 4,363,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6483 ug/kg
- TOXIC EFFECTS :
- Behavioral - analgesia
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 145,11,1964
