1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,(2S,3S)-
- 中文别名：地尔硫卓
- 中文释义：地尔硫卓;5-[2-(二甲基氨基)乙基]-2-(4-甲氧基苯基)-4-氧代-2,3,4,5-四氢-1,5-苯并硫氮杂卓-3-基乙酸酯
- 英文别名：diltiazem;
Coras;
Adizem XL;
TILDIEM300LP;
Diltiazem;
DILTIAZEN
- CAS No.：42399-41-7
- 分子式：
C22H26N2O4S
- 分子量：414.52
- 精确分子量：414.16100
- PSA：84.38000
- InChI：InChI=1/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m1/s1
- 分子结构式：
物化性质
- 密度：
- 1.26 g/cm3
- 沸点：
- 594.4ºC at 760 mmHg
- 闪点：
- 313.3ºC
安全信息
- 密度：
- 1.26 g/cm3
- 沸点：
- 594.4ºC at 760 mmHg
- 闪点：
- 313.3ºC
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DL0280000
- CHEMICAL NAME :
- 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro- 2-(4- methoxyphenyl)-, (2S-cis)-
- CAS REGISTRY NUMBER :
- 42399-41-7
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C22-H26-N2-O4-S
- MOLECULAR WEIGHT :
- 414.56
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 740 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,121,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 61 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,121,1991
